2024

Cav3.1 is a leucine sensor in POMC neurons mediating appetite suppression and weight loss. 

Anthony H. Tsang, Nicholas Heeley, Constanza Alcaino, Eunsang Hwang, Brian Y. Lam, Taufiq Rahman, Tamana Darwish, Danae Nuzzaci, Richard G. Kay, Amar Sarkar, Ruiyan Wang, Nihal Basha, Austin Punnoose, Peter Kirwan, Marcella Ma, Giles S. Yeo, Florian T. Merkle, Fiona M. Gribble, Frank Reinmann, Kevin Williams, Clemence Blouet

https://biorxiv.org/cgi/content/short/2024.09.13.612843v1

https://doi.org/10.1101/2024.09.13.612843

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Adult oligodendrogenesis gates arcuate neuronal glucose sensing through remodelling of the blood-hypothalamus barrier via ADAMTS4

Sophie Buller, Emily Staricoff, Christine Riches, Anthony Tsang, Masa Josipovic, Kentaro Ikemura, Gabriel Opoku, Ikumi Sato, Satoshi Hirohata, Saskia Stenzel, Stuart Nayar, Marta Ramos Vega, Jacob Hecksher-Sorensen, Sebastian Timmler, Georgina Dowsett, Brian Lam, Giles S.H. Yeo, Kimberly M. Alonge, Huiliang Li, William D. Richardson, Mark L. Evans, Clemence Blouet

https://www.biorxiv.org/content/10.1101/2024.09.10.612227v1

https://doi.org/10.1101/2024.09.10.612227

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Glucose-Dependent Insulinotropic Polypeptide Receptor Signalling in Oligodendrocytes Increases the Weight Loss Action of GLP-1R Agonism.

Robert Hansford, Sophie Buller, Anthony H. Tsang, Simon Benoit, Anna Roberts, Emmy Erskine, Valentina Pirro, Frank Reimann, Noria Harada, Nobuya Inagaki, Alice Adrienssens, Ricardo Samms, Clemence Blouet.

​http://dx.doi.org/10.2139/ssrn.4704168

https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4704168

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Brain access of incretins and incretin receptor agonists to their central targets relevant for appetite suppression and weight loss.

Sophie Buller, Clemence Blouet. 

doi: 10.1152/ajpendo.00250.2023

Am J Physiol Endocrinol Metab​ 2024 

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2023

Median eminence myelin continuously turns over in adult mice. Buller S, Kohnke S, Hansford R, Shimizu T, Richardson WD, Blouet C. Mol Metab. 2023

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A pipeline for identification and validation of brain targets for weight loss. Tsang A, Blouet C. Nat Rev Endocrinol. 2023

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2021

Nutritional regulation of oligodendrocyte differentiation regulates perineuronal net remodeling in the median eminence. Kohnke S, Buller S, Nuzzaci D, Ridley K, Lam B, Pivonkova H, Bentsen MA, Alonge KM, Zhao C, Tadross J, Holmqvist S, Shimizo T, Hathaway H, Li H, Macklin W, Schwartz MW, Richardson WD, Yeo GSH, Franklin RJM, Karadottir RT, Rowitch DH, Blouet C. Cell Reports, 2021

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Behavioural and neurochemical mechanisms underpinning the feeding-suppressive effect of GLP-1/CCK combinatorial therapy. Roth E, Benoit S, Quentin B, Lam B, Will S, Ma M, Heeley N, Darwish T, Shrestha Y, Gribble F, Reimann F, Pshenichnaya I, Yeo G, Baker DJ, Trevaskis JL, Blouet C.Mol Metab. 2021 

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2020

Calcitonin Receptor Neurons in the Mouse Nucleus Tractus Solitarius Control Energy Balance via the Non-aversive Suppression of Feeding. W Cheng, I Gonzalez, W Pan, AH Tsang, J Adams, E Ndoka, D Gordian, B Khoury, K Roelofs, S Evers, A MacKinnon, S Wu, H Frikke-Schmidt, JN Flak, JL Trevaskis,CJ Rhodes, S Fukada, RJ Seeley, DA Sandoval, DP Olson, C Blouet, MG MyersJr. Cell Metab. 2020 Jan.

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Nutrient sensing in the nucleus of the solitary tract mediates non-aversive suppression of feeding via inhibition of AgRP neurons. Tsang AH, Nuzzaci D, Darwish T, Samudrala H, Blouet C.Mol Metab. 2020

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2019

Hypothalamic dopamine signaling regulates brown fat thermogenesis. Folgueira C, Beiroa D, Porteiro B, Duquenne M, Puighermanal E, Fondevila MF, Barja-Fernández S, Gallego R, Hernández-Bautista R, Castelao C, Senra A, Seoane P, Gómez N, Aguiar P, Guallar D, Fidalgo M, Romero-Pico A, Adan R, Blouet C, Labandeira-García JL, Jeanrenaud F, Kallo I, Liposits Z, Salvador J, Prevot V, Dieguez C, Lopez M, Valjent E, Frühbeck G, Seoane LM, Nogueiras R.

Nat Metab. 2019 Aug;1(8):811-829.

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Nutritional signals rapidly activate oligodendrocyte differentiation in the adult hypothalamic median eminence, BiorXiv preprint

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Glucose-Dependent Insulinotropic Polypeptide Receptor-Expressing Cells in the Hypothalamus Regulate Food Intake. Adriaenssens AE, Biggs EK, Darwish T, Tadross J, Sukthankar T, Girish M, Polex-Wolf J, Lam BY, Zvetkova I, Pan W, Chiarugi D, Yeo GSH, Blouet C, Gribble FM, Reimann F. Cell Metab. 2019 Aug 19

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Mapping neuronal inputs to Kiss1 neurons in the arcuate nucleus of the mouse. Yeo SH, Kyle V, Blouet C, Jones S, Colledge WH. PLoS One. 2019 Mar 27;14(3)

 

2018

A GLP-1:CCK fusion peptide harnesses the synergistic effects on metabolism of CCK-1 and GLP-1 receptor agonism in mice. Hornigold DC, Roth E, Howard V, Will S, Oldham S, Coghlan MP, Blouet C, Trevaskis JL.

Appetite. 2018 Aug 1

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Rapid sensing of l-leucine by human and murine hypothalamic neurons: Neurochemical and mechanistic insights.

Heeley N, Kirwan P, Darwish T, Arnaud M, Evans ML, Merkle FT, Reimann F, Gribble FM, Blouet C.

Mol Metab. 2018 Feb 7.

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A gut-brain axis regulating glucose metabolism mediated by bile acids and competitive fibroblast growth factor actions at the hypothalamus.

Liu S, Marcelin G, Blouet C, Jeong JH, Jo YH, Schwartz GJ, Chua S Jr..

Mol Metab. 2018 Feb;8:37-50

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Melanin-Concentrating Hormone acts through hypothalamic kappa opioid system and p70S6K to stimulate acute food intake.

Romero-Picó A, Sanchez-Rebordelo E, Imbernon M, González-Touceda D, Folgueira C, Senra A, Fernø J, Blouet C, Cabrera R, van Gestel M, Adan RA, López M, Maldonado R, Nogueiras R, Diéguez C.

Neuropharmacology. 2018 Mar 1;130:62-70.

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2017

mTORC1 in AGRP neurons integrates exteroceptive and interoceptive food-related cues in the modulation of adaptive energy expenditure in mice.

Burke LK, Darwish T, Cavanaugh AR, Virtue S, Roth E, Morro J, Liu SM, Xia J, Dalley JW, Burling K, Chua S, Vidal-Puig T, Schwartz GJ, Blouet C.

Elife. 2017 May 23;6.

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Heterogeneity of hypothalamic pro-opiomelanocortin-expressing neurons revealed by single-cell RNA sequencing.

Lam BYH, Cimino I, Polex-Wolf J, Nicole Kohnke S, Rimmington D, Iyemere V, Heeley N, Cossetti C, Schulte R, Saraiva LR, Logan DW, Blouet C, O'Rahilly S, Coll AP, Yeo GSH.

Mol Metab. 2017 Mar 1;6(5):383-392. 

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2016

Central Amino Acid Sensing in the Control of Feeding Behavior.

Heeley N, Blouet C.

Front Endocrinol (Lausanne). 2016 Nov 23;7:148.

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2015

Cholinergic neurons in the dorsomedial hypothalamus regulate mouse brown adipose tissue metabolism.

Jeong JH, Lee DK, Blouet C, Ruiz HH, Buettner C, Chua S Jr, Schwartz GJ, Jo YH.

Mol Metab. 2015 Apr 11;4(6):483-92. doi: 10.1016/j.molmet.2015.03.006.

 

High-fat feeding impairs nutrient sensing and gut brain integration in the caudomedial nucleus of the solitary tract in mice.

Cavanaugh AR, Schwartz GJ, Blouet C.

PLoS One. 2015 Mar 16;10(3):e0118888. doi: 10.1371/journal.pone.0118888.

 

2013

 

Central action of FGF19 reduces hypothalamic AGRP/NPY neuron activity and improves glucose metabolism.

Marcelin G, Jo YH, Li X, Schwartz GJ, Zhang Y, Dun NJ, Lyu RM, Blouet C, Chang JK, Chua S Jr.

Mol Metab. 2013 Oct 23;3(1):19-28. doi: 10.1016/j.molmet.2013.10.002.

 

[Role of the nucleus of the solitary tract in the detection and integration of multiple metabolic signals].

Blouet C.

Med Sci (Paris). 2013 May;29(5):449-52. doi: 10.1051/medsci/2013295002. French. No abstract available.

 

2012

 

Duodenal lipid sensing activates vagal afferents to regulate non-shivering brown fat thermogenesis in rats.

Blouet C, Schwartz GJ.

PLoS One. 2012;7(12):e51898. doi: 10.1371/journal.pone.0051898.

 

Brainstem nutrient sensing in the nucleus of the solitary tract inhibits feeding.

Blouet C, Schwartz GJ.

Cell Metab. 2012 Nov 7;16(5):579-87.

 

TXNIP in Agrp neurons regulates adiposity, energy expenditure, and central leptin sensitivity.

Blouet C, Liu SM, Jo YH, Chua S, Schwartz GJ.

J Neurosci. 2012 Jul 18;32(29):9870-7. doi: 10.1523/JNEUROSCI.0353-12.2012.

 

2011

 

Nutrient-sensing hypothalamic TXNIP links nutrient excess to energy imbalance in mice.

Blouet C, Schwartz GJ.

J Neurosci. 2011 Apr 20;31(16):6019-27. doi: 10.1523/JNEUROSCI.6498-10.2011.

 

2010

 

Hypothalamic nutrient sensing in the control of energy homeostasis.

Blouet C, Schwartz GJ.

Behav Brain Res. 2010 May 1;209(1):1-12. doi: 10.1016/j.bbr.2009.12.024. Review.

 

2009

 

Mediobasal hypothalamic leucine sensing regulates food intake through activation of a hypothalamus-brainstem circuit.

Blouet C, Jo YH, Li X, Schwartz GJ.

J Neurosci. 2009 Jul 1;29(26):8302-11. doi: 10.1523/JNEUROSCI.1668-09.2009.

 

2008

 

Mediobasal hypothalamic p70 S6 kinase 1 modulates the control of energy homeostasis.

Blouet C, Ono H, Schwartz GJ.

Cell Metab. 2008 Dec;8(6):459-67. doi: 10.1016/j.cmet.2008.10.004.

PMID:

 

Nitric oxide bioavailability and not production is first altered during the onset of insulin resistance in sucrose-fed rats.

Blouet C, Mariotti F, Mathe V, Tome D, Huneau JF.

Exp Biol Med (Maywood). 2007 Dec;232(11):1458-64. Erratum in: Exp Biol Med (Maywood). 2008 Apr;233(4):492.

 

2007

 

Dietary cysteine alleviates sucrose-induced oxidative stress and insulin resistance.

Blouet C, Mariotti F, Azzout-Marniche D, Mathé V, Mikogami T, Tomé D, Huneau JF.

Free Radic Biol Med. 2007 Apr 1;42(7):1089-97.

 

Liver glyconeogenesis: a pathway to cope with postprandial amino acid excess in high-protein fed rats?

Azzout-Marniche D, Gaudichon C, Blouet C, Bos C, Mathé V, Huneau JF, Tomé D.

Am J Physiol Regul Integr Comp Physiol. 2007 Apr;292(4):R1400-7.

 

Meal cysteine improves postprandial glucose control in rats fed a high-sucrose meal.

Blouet C, Mariotti F, Mikogami T, Tome D, Huneau JF.

J Nutr Biochem. 2007 Aug;18(8):519-24.

 

2006

 

Medium-term methionine supplementation increases plasma homocysteine but not ADMA and improves blood pressure control in rats fed a diet rich in protein and adequate in folate and choline.

Mariotti F, Hammiche A, Blouet C, Daré S, Tomé D, Huneau JF.

Eur J Nutr. 2006 Oct;45(7):383-90.

 

The reduced energy intake of rats fed a high-protein low-carbohydrate diet explains the lower fat deposition, but macronutrient substitution accounts for the improved glycemic control.

Blouet C, Mariotti F, Azzout-Marniche D, Bos C, Mathé V, Tomé D, Huneau JF.

J Nutr. 2006 Jul;136(7):1849-54.